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1 More recently, reviews from the Breast International Group 1-98 trial2,3 and the Arimidex, Tamoxifen, Alone or in Combina-tion trial 4,5 showed that 5 years of adjuvant therapy with an aromatase inhibitor alone improved disease-free survival in comparison with 5 years of tamoxifen therapy; other large studies showed that switching to an aromatase inhibitor after preliminary treatment with tamoxifen improved survival.6-12 A meta-analysis13 of trials of initial and sequential strategies supported the recommendation in guidelines an aromatase inhibitor ought to be contained in adjuvant therapy for postmenopausal females with endocrine-responsive early breasts cancer generic levitra .14-16 In the BIG 1-98 study, we compared monotherapy with tamoxifen, monotherapy with an aromatase inhibitor, and two sequential treatments: tamoxifen followed by an aromatase inhibitor and an aromatase inhibitor followed by tamoxifen.

The FOXL2 mutation was absent in 149 various other epithelial ovarian tumors and in 180 breasts cancers . Sample GCT18, a thecoma, was the only non-GCT tumor that was positive for the FOXL2 variant in the initial validation series. Further analysis of this sample revealed a minor granulosa-cell component . 7 in the Supplementary Appendix). By sequencing cloned PCR products, we observed that these variants had been in cis. We carried out fluorescence in situ hybridization to assess potential amplification of FOXL2 on 32 GCTs and 5 epithelial ovarian cancers and acquired negative outcomes . Test for Replication We obtained a second series of 95 clinical samples to determine the specificity of the variant within SCSTs of the ovary .