Antidepressants can accelerate bone loss

The men in the study who took SSRIs had lower bone density of the hip and lower back that men who were not taking antidepressants. There were no significant differences between those who took tricyclic antidepressants and the men who were not taking antidepressants.The best chance to do this is to encourage the FDA and require drug companies to collect this information in future studies, he said.

The results were similar in a study of nearly 6000 men aged 65 years.

Because depression is associated with an increased risk of bone loss in older people, a better understanding of the effects of antidepressants on the bone is urgent, he said.

Although it is not nice to use a second drug to drive the negative effects of a first, if necessary, there are many good options that exist to prevent bone loss, he writes.

This sounds very alarming, but we really know if t is clinically significant, and we can not say with certainty that the use of SSRIs was the result of a loss of bone tissue, Diem said. These preliminary results that need to be confirmed.

About 200 of these women were SSRI users, and 118 took tricyclic antidepressants and 2,406 had no antidepressant.

SSRIs benefit many people, and nobody should stop taking these drugs on the basis of these results, said Diem. But it is clear that this must be examined further. Studies of bone loss in the new SSRIs

In an editorial accompanying the two studies, Saag noted that the benefits of SSRIs may outweigh the risks for many older people with depression.

In one study, older women who took SSRI antidepressants have shown an acceleration of 60 percent of bone loss than women who did not take antidepressants, researcher Susan J. Diem, MD, MPH, tells WebMD.

In one of the highest, reported in January, researchers in Canada have found the use of SSRIs to be associated with a doubling of the risk of fractures associated with bone loss.

The accelerated bone loss was not observed in women who took another type of antidepressant.

All in all men and women – seem to link the use of selective serotonin reuptake inhibitors for the weakening of bones due to aging.

Osteoporosis researcher Kenneth Saag, MD, tells WebMD that the pharmaceutical companies that develop new drugs SSRIs should be kept on their medication’s impact on bone health.

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