First-degree relatives of patients with bicuspid aortic valve should be examined

If you know a parent is bicuspid aortic valve, then you know you should be examined, said study author Kirsten Tolstrup, MD, deputy director of the non-invasive cardiology laboratory at the Institute of Cedars-Sinai Heart. SRF seems to be a genetic disease that has many different events, so we will study the genes.The results suggest that patients with bicuspid aortic valve, and first-degree relatives should have a screening echocardiogram to evaluate for dilated aorta and bicuspid aortic valve.

The study, conducted among 54 patients with bicuspid aortic valve and 48 first-degree relatives of these patients and 45 matched controls found: 32 % of apparently healthy first-degree relatives have enlarged aortas

Bicuspid aortic valve , a condition in which the aortic valves of patients only two leaflets instead of three normal heart defect is the most common, affecting up to two % of the general population. Failure can result in deposition of calcification of heart valve, a drain valve and the results are a feeling of chest tightness and shortness of breath. The condition is easily diagnosed and often doctors may hear a click or a breath when they hear the heart of a patient with BAV stethoscope.

Studies have shown that BAV is likely genetic, although the gene has not been identified, and in some families, the incidence of this defect may take up to 20 %.

The audit, which appear in the 2010 edition of the magazine in September of the RCR Clinical Oncology, looked at more than 1200 patients treated with radiotherapy in cancer centers in the United Kingdom in 2001 and 2002. Patients treated with radiotherapy and those treated with chemotherapy, were compared for survival, recurrence of the disease and complications after treatment.

The statistical analysis of study data showed that survival was significantly better in patients treated with radiochemotherapy without increasing late complications than patients treated with radiotherapy alone.